Cancer statistics, 2019 – Siegel – 2019 – CA: A Cancer Journal for Clinicians – Wiley Online Library

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via Cancer statistics, 2019 – Siegel – 2019 – CA: A Cancer Journal for Clinicians – Wiley Online Library

Selected Findings

Expected Numbers of New Cancer Cases

Table 1 presents the estimated numbers of new cases of invasive cancer in the United States in 2019 by sex and cancer type. In total, there will be approximately 1,762,450 cancer cases diagnosed, which is the equivalent of more than 4,800 new cases each day. In addition, there will be approximately 62,930 new cases of female breast carcinoma in situ and 95,830 new cases of melanoma in situ of the skin. The estimated numbers of new cases by state are shown in Table 2.

Table 1. Estimated New Cancer Cases and Deaths by Sex, United States, 2019*
ESTIMATED NEW CASES ESTIMATED DEATHS
BOTH SEXES MALE FEMALE BOTH SEXES MALE FEMALE
All sites 1,762,450 870,970 891,480 606,880 321,670 285,210
Oral cavity & pharynx 53,000 38,140 14,860 10,860 7,970 2,890
Tongue 17,060 12,550 4,510 3,020 2,220 800
Mouth 14,310 8,430 5,880 2,740 1,800 940
Pharynx 17,870 14,450 3,420 3,450 2,660 790
Other oral cavity 3,760 2,710 1,050 1,650 1,290 360
Digestive system 328,030 186,080 141,950 165,460 97,110 68,350
Esophagus 17,650 13,750 3,900 16,080 13,020 3,060
Stomach 27,510 17,230 10,280 11,140 6,800 4,340
Small intestine 10,590 5,610 4,980 1,590 890 700
Colon † 101,420 51,690 49,730 51,020 27,640 23,380
Rectum 44,180 26,810 17,370
Anus, anal canal, & anorectum 8,300 2,770 5,530 1,280 520 760
Liver & intrahepatic bile duct 42,030 29,480 12,550 31,780 21,600 10,180
Gallbladder & other biliary 12,360 5,810 6,550 3,960 1,610 2,350
Pancreas 56,770 29,940 26,830 45,750 23,800 21,950
Other digestive organs 7,220 2,990 4,230 2,860 1,230 1,630
Respiratory system 246,440 130,370 116,070 147,510 80,380 67,130
Larynx 12,410 9,860 2,550 3,760 3,010 750
Lung & bronchus 228,150 116,440 111,710 142,670 76,650 66,020
Other respiratory organs 5,880 4,070 1,810 1,080 720 360
Bones & joints 3,500 2,030 1,470 1,660 960 700
Soft tissue (including heart) 12,750 7,240 5,510 5,270 2,840 2,430
Skin (excluding basal & squamous) 104,350 62,320 42,030 11,650 8,030 3,620
Melanoma of the skin 96,480 57,220 39,260 7,230 4,740 2,490
Other nonepithelial skin 7,870 5,100 2,770 4,420 3,290 1,130
Breast 271,270 2,670 268,600 42,260 500 41,760
Genital system 295,290 186,290 109,000 65,540 32,440 33,100
Uterine cervix 13,170 13,170 4,250 4,250
Uterine corpus 61,880 61,880 12,160 12,160
Ovary 22,530 22,530 13,980 13,980
Vulva 6,070 6,070 1,280 1,280
Vagina & other genital, female 5,350 5,350 1,430 1,430
Prostate 174,650 174,650 31,620 31,620
Testis 9,560 9,560 410 410
Penis & other genital, male 2,080 2,080 410 410
Urinary system 158,220 108,450 49,770 33,420 23,290 10,130
Urinary bladder 80,470 61,700 18,770 17,670 12,870 4,800
Kidney & renal pelvis 73,820 44,120 29,700 14,770 9,820 4,950
Ureter & other urinary organs 3,930 2,630 1,300 980 600 380
Eye & orbit 3,360 1,860 1,500 370 200 170
Brain & other nervous system 23,820 13,410 10,410 17,760 9,910 7,850
Endocrine system 54,740 15,650 39,090 3,210 1,560 1,650
Thyroid 52,070 14,260 37,810 2,170 1,020 1,150
Other endocrine 2,670 1,390 1,280 1,040 540 500
Lymphoma 82,310 45,660 36,650 20,970 12,100 8,870
Hodgkin lymphoma 8,110 4,570 3,540 1,000 590 410
Non‐Hodgkin lymphoma 74,200 41,090 33,110 19,970 11,510 8,460
Myeloma 32,110 18,130 13,980 12,960 6,990 5,970
Leukemia 61,780 35,920 25,860 22,840 13,150 9,690
Acute lymphocytic leukemia 5,930 3,280 2,650 1,500 850 650
Chronic lymphocytic leukemia 20,720 12,880 7,840 3,930 2,220 1,710
Acute myeloid leukemia 21,450 11,650 9,800 10,920 6,290 4,630
Chronic myeloid leukemia 8,990 5,250 3,740 1,140 660 480
Other leukemia ‡ 4,690 2,860 1,830 5,350 3,130 2,220
Other & unspecified primary sites  31,480 16,750 14,730 45,140 24,240 20,900
  • Rounded to the nearest 10; cases exclude basal cell and squamous cell skin cancers and in situ carcinoma except urinary bladder. Approximately 62,930 cases of carcinoma in situ of the female breast and 95,830 cases of melanoma in situ will be newly diagnosed in 2019.
  •  Deaths for colon and rectal cancers are combined because a large number of deaths from rectal cancer are misclassified as colon.
  •  More deaths than cases may reflect a lack of specificity in recording the underlying cause of death on death certificates and/or an undercount in the case estimate.
  • Note: These are model‐based estimates that should be interpreted with caution and not compared with those for previous years.

Figure 1 depicts the most common cancers expected to be diagnosed in men and women in 2019. Prostate, lung and bronchus (referred to as lung hereafter), and colorectal cancers (CRCs) account for 42% of all cases in men, with prostate cancer alone accounting for nearly 1 in 5 new diagnoses. For women, the 3 most common cancers are breast, lung, and colorectum, which collectively represent one‐half of all new diagnoses; breast cancer alone accounts for 30% of all new cancer diagnoses in women.

image
Ten Leading Cancer Types for the Estimated New Cancer Cases and Deaths by Sex, United States, 2019. Estimates are rounded to the nearest 10 and exclude basal cell and squamous cell skin cancers and in situ carcinoma except urinary bladder. Ranking is based on modeled projections and may differ from the most recent observed data.

The lifetime probability of being diagnosed with invasive cancer is slightly higher for men (39.3%) than for women (37.7%) (Table 3). The reasons for the excess risk in men are not fully understood, but partly reflect differences in environmental exposures, endogenous hormones, and probably complex interactions between these influences. Recent research suggests that sex differences in immune function and response may also play a role.25 Adult height, which is determined by genetics and childhood nutrition, is positively associated with cancer incidence and mortality in both men and women,26 and has been estimated to account for one‐third of the sex disparity.27

 

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